The Edmonton Protocol
Before the Edmonton protocol was developed, researchers used steroid-based immunosuppressant regimens. Many of these drugs damaged the insulin-producing cells or made recipients insulin resistant, which made more work for the new islets.
In the late 1990s, Dr. James Shapiro and colleagues at the University of Alberta, in Edmonton, Canada, introduced the following changes:
The Edmonton protocol has been adapted by islet transplant centers worldwide. Over 500 islet transplant procedures have been done with some variant of this protocol.